Title: How Systems Biology can help to decipher Design Principles of Biochemical Networks – The Cell Division Cycle as a test case.
Date: Noon – 1 pm, January 23rd, 2020 (Thursday).
Location: Thomas 3503 (Pizza lunch will be provided. Seminar co-hosted by Synthetic & Systems Biology cluster and Quantitative & Computational Developmental Biology cluster).
Matteo Barberis
Systems Biology, School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, GU2 7XH Guildford, Surrey, United Kingdom
Continuity of life is sustained by time-dependent responses of biological networks that are associated to oscillatory behavior of their components. The eukaryotic cell cycle is such an example, with a cascade of enzymatic waves of activity being switched ON and OFF according to a definite pattern, to guarantee its completion. Therefore, molecular designs underlying enzymatic oscillations are inherently crucial for a timely cell division. In this seminar, I will show how we integrate computational and experimental strategies, to investigate molecular designs interlocking enzymatic activities with transcriptional or metabolic regulations. Our work aims to the identification of novel principles of design that may ensure a timely cell cycling.